Chronic renal failure, which can cause kidney changes

The occurrence and development of chronic renal failure can occur a series of compensatory response structure and function of the kidneys, in order to make the body adapt to the body due to the reduced number of units of renal function caused by various changes, maintain the balance of the body. These compensatory response of the structure and function mainly includes the following aspects:

① increase in residual nephrons glomerular filtration rate, action to compensate for the loss of function of the nephron, the body excrete metabolic waste, but residual renal units due to the load increase, and further accelerate the glomerular damage, such as causing kidney pellets hypertrophy;

② compensatory glomerular hypertrophy, although no adverse reactions in intact nephrons, but also can enhance renal function, but in the glomerular diseases can cause decreased glomerular filtration rate secondary, accelerated glomerular hardening;

③ glomerular and interstitial inflammatory cell infiltration, can swallow, remove cause glomerular and tubular lesions harmful substances, but can also release growth factors and inflammatory mediators, stimulate collagen deposition and mesangial matrix increase, leading to renal Ball sclerosis and interstitial fibrosis occurs in renal;

④ increase in residual renal sodium excretion units can be prevented extracellular fluid expansion and hypertension produce, but can be caused by low sodium intake reduced capacity response;

⑤ renal tubular secretion of ammonia increased, although you can reduce the production of acid poisoning, but accelerated tubulointerstitial damage;

⑥ urinary protein excretion may lead to patient edema, hypoalbuminemia, and accelerate renal tubular glomerular damage;

⑦ secondary hyperparathyroidism, so that the body increases the excretion of phosphorus, reducing the phosphorus retention, but its consequences are caused disorder and imbalance uremic bone disease and other organ function.

Thus, compensatory response in chronic renal failure occurred during a series of kidney structure and function, although you can partially corrected nephron loss resulting from a series of pathophysiological changes, but if you do not artificially be actively controlled, They are likely to have adverse effects to the body, can eventually lead to glomerulosclerosis and tubulointerstitial damage.

http://www.kidneyhospitalabroad.com/Christmas/index.html
kidneyhospitalabroad@hotmail.com
WhatsApp:+8615511395691
Viber:+8613393010526